PA143049
Factor XII Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA143049-Each-of-1 | In Stock | ₹ 29,147.50 |
PA143049 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 29,147.50
GST (18%): ₹ 5,246.55
Total Price: ₹ 34,394.05
Antigen
Factor XII
Classification
Polyclonal
Conjugate
Unconjugated
Gene
F12
Gene Alias
beta-factor XIIa part 1; Beta-factor XIIa part 2; coagulation factor XII; coagulation factor XII (Hageman factor); coagulation factor XIIa heavy chain; Coagulation factor XIIa light chain; F12; F13; Factor 12; factor XII; Factor12; FXII; HAE3; HAEX; HAF; hageman factor
Host Species
Sheep
Purification Method
Ammonium sulfate precipitation, Ion-exchange chromatography
Regulatory Status
RUO
Gene ID (Entrez)
2161
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
ELISA, Western Blot
Concentration
14.4 mg/mL
Formulation
50% water with 50% glycerol and no preservative
Gene Accession No.
P00748
Gene Symbols
F12
Immunogen
Human Factor XII.
Quantity
1 mg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-43049 detects Factor XII in human samples
- PA1-43049 has successfully been used in Western blot and ELISA applications
- PA1-43049 was derived from human factor XII
- This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain
- The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain
- On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain
- Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa
- The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin
- It activates coagulation factors VII and XI
- Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.