ATG5 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA146178-Each-of-1 | In Stock | ₹ 52,109.50 |
PA146178 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,109.50
GST (18%): ₹ 9,379.71
Total Price: ₹ 61,489.21
Antigen
ATG5
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Atg5
Gene Alias
2010107M05Rik; 3110067M24Rik; APG 5; APG5; APG5 autophagy 5 like (APG5L); APG5 autophagy 5-like protein; APG5 autophagy 5-like protein, isoform 1; APG5L; APG5-LIKE; apoptosis-specific protein; Apoptosis-specific protein (ASP); ASP; atg5; Atg-5; ATG5 autophagy related 5 homolog; ATG5 autophagy related 5 homolog (S. cerevisiae); atg5.L; Atg5l; Atg5-PA; autophagy 5-like protein; autophagy protein 5; autophagy related 5; autophagy related 5 L homeolog; autophagy related 5-like protein; Autophagy-related 5; autophagy-specific gene 5; AW319544; C88337; CG1643; CG1643-PA; DmAtg5; Dmel\CG1643; Dmel_CG1643; hAPG5; hypothetical protein LOC532686; LD34980p; Paddy; XELAEV_18027227mg; zgc:100934
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
100735170, 100739102, 11793, 31666, 365601, 443756, 494180, 532686, 641362, 9474
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Proximity Ligation Assay, Radioimmune Assays (RIA), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
Q3MQ04, Q3MQ06, Q3MQ24, Q99J83, Q9H1Y0, Q9W3R7
Gene Symbols
Atg5, atg5.L
Immunogen
Synthetic peptide made to an N-terminal region of the human ATG5 protein.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Bovine, Drosophila, Fish, Guinea Pig, Human, Mouse, Non-human Primate, Porcine, Rat, Reptile, X. laevis, Zebrafish
Product Type
Antibody
Isotype
IgG
Related Products
Description
- In Western Blot, a band is seen ∽56 kDa representing the ATG5-ATG12 complex, the molecular weight of human ATG5 is ∽33 kDa
- Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended
- Suggested positive control: antigen standard for ATG5 (transient overexpression lysate), mouse wildtype ES cell lysate
- ATG5 (Autophagy Related 5) is an important element for autophagy and may play an important role in the apoptotic process
- ATG5 is also involved in other cellular processes that include mitochondrial quality control after oxidative damage, negative regulation of the innate anti-viral immune response, lymphocyte development and proliferation, MHC II antigen presentation, and adipocyte differentiation
- Following conjugation to ATG12, the conjugate participates in the formation of autophagosome
- ATG5 contributes to autophagic cell death by interacting with Fas-associated protein with death domain (FADD)
- The ATG5-ATG12 conjugate forms a cup-shaped isolation membrane that then detaches from the membrane immediately before or after autophagosome formation is completed
- APG5 may play a role in the apoptotic process, possibly within the modified cytoskeleton
- Further, APG5 expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity
- The APG5-APG12 conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells
- Diseases associated with ATG5 dysfunction include spinocerebellar ataxia.