Phospho-ELK1 (Ser383) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA14625-Each-of-1 | In Stock | ₹ 48,905.50 |
PA14625 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
Phospho-ELK1 (Ser383)
Classification
Polyclonal
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.
A4GTP4, P19419, P41969
Gene Symbols
ELK1
Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser383 of human ELK1 conjugated to KLH
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Conjugate
Unconjugated
Gene
ELK1
Gene Alias
ELK 1; ELK1; Elk-1; ELK1, ETS transcription factor; ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1; ETS transcription factor ELK1; ETS-like gene 1; Oncogene Elk1; tyrosine kinase (ELK1) oncogene
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
13712, 2002, 314436
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- This antibody is predicted to react with canine, mouse, non-human primate and zebrafish based on 100% sequence homology
- This antibody is specific for ∽46 kDa Elk-1 phosphorylated at Ser383 in Western blots using phospho and dephospho Elk-1 recombinant protein
- Immunolabeling is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide
- ELK1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors
- ELK1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus
- Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by ELK1
- ELK1 appears to be a direct target of activated MAP kinase
- Biochemical studies indicate that ELK1 is a good substrate for MAP kinase, the kinetics of ELK1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block ELK1 activation in vivo
- ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade
- Alternatively spliced transcript variants encoding the same protein have been found for ELK1.