Endostatin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1601-Each-of-1 | In Stock | ₹ 50,240.50 |
PA1601 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,240.50
GST (18%): ₹ 9,043.29
Total Price: ₹ 59,283.79
Antigen
Endostatin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
COL18A1
Gene Alias
antiangiogenic agent; Col18a1; Collagen alpha-1(XVIII) chain; collagen type XVIII alpha 1 chain; collagen, type XVIII, alpha 1; endostatin; FLJ27325; FLJ34914; KNO; KNO1; KS; MGC74745; multi-functional protein MFP; NC1; Non-collagenous domain 1; procollagen, type XVIII, alpha 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12822, 80781
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P39060, P39061
Gene Symbols
COL18A1
Immunogen
Synthetic Peptide: R(129) R L M/T E S Y C E T W R T E(142)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-601 detects recombinant human and mouse endostatin
- PA1-601 has been successfully used in Western blot, IF/ICC and IHC (P) procedures
- By Western blot, this antibody detects a 20 kDa protein representing recombinant human endostatin
- PA1-601 immunizing peptides are two peptides derived from mouse and human endostatin protein corresponding to amino acid residues 129-142 of endostatin
- PA1-601 can be used with blocking peptide PEP-112
- Endostatin is able to avoke non-uniform response for proliferation, cell mount and migration of entothelial cells, which different endostatin binding characteristic, leads to the assumption that endostatin effect is strongly dependent from endothelial cell type
- Furthermore endostatin inhibits angiogenesis and tumor growth in vivo by inducing apoptosis in endothelial cells
- The local delivery of endostatin seems to specifically affect tumor-associated microvessels by reduction of the vessel density, diameter and functionality
- Tumor cell migration and invasion was greatly reduced in the endostatin treated animals
- Endostatin is non-toxic and does not induce aquired drug resistance and has therefor become a potent new therapy strategy in solid neoplasias
- This therapy appears to have a high potential not only for the treatment of gliomas, the most common brain tumors, but also in other tumors
- The ability of endostatin to inhibit neoangiogenesis is mediated, at least in part, by Zn^+2 binding and elastase processing
- Widespread endostatin expression was found in elactic fibers in vessel walls and in some other basement membrane zones
- Endostatin is released by neurons to accumulate in amyloid plaques in Alzheimer's disease.