CLAC-P Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA14308-Each-of-1 | In Stock | ₹ 47,036.50 |
PA14308 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,036.50
GST (18%): ₹ 8,466.57
Total Price: ₹ 55,503.07
Antigen
CLAC-P
Classification
Polyclonal
Conjugate
Unconjugated
Gene
COL25A1
Gene Alias
2700062B08Rik; Alzheimer disease amyloid-associated protein; AMY; CFEOM5; CLAC; CLACP; CLAC-P; Col25a1; collagen alpha-1(XXV) chain; collagen type XXV alpha 1; collagen, type XXV, alpha 1; collagen-like Alzheimer amyloid plaque component; collagenous Alzheimer amyloid plaque component; procollagen, type XXV, alpha 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
77018, 84570
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
Q99MQ5, Q9BXS0
Gene Symbols
COL25A1
Immunogen
Synthetic peptide: D(430) Y N G N L H E A L Q R I T(443) of the NC3 region of human and murine CLAC-P
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-4308 detects CLAC-P (NC3 region) in human and mouse samples
- PA1-4308 has been successfully used in Western blotting and immunohistochemistry procedures
- By Western blot, this antibody detects a ∽70 kDa protein representing CLAC-P (NC3 region) in stable HEK293T cell lines expressing CLAC-P (NC3 region)
- PA1-4308 does not cross react with COLXIII or COLXXIII proteins
- PA1-4308 immunizing peptide corresponds to amino acid residues 430-443 of the NC3 region of human and mouse CLAC-P
- Maintain at 4oC for 3 months or at -20oC for longer periods
- Avoid freeze/thaw cycles
- Alzheimer’s disease (AD) is characterized by deposition of beta-amyloid as senile plaques and cerebral amyloid angiopathy
- The principal component of AD amyloid is the amyloid beta peptide (A beta)
- Although production and deposition of A beta appear closely related to the pathogenesis of AD, current evidence suggest that A beta alone is not sufficient to cause neuronal death and symptoms of dementia
- A component of senile plaque (SP), CLAC (collagen-like Alzheimer amyloid plaque component ) and its precursor CLAC-P are deposited with extracellular beta-amyloid and have been recently implicated in cell toxicity of beta-amyloid in AD brains
- CLAC-P is a unique, membrane-bound collagen-like structure containing three Gly-X-Y repeat motifs and may define a novel class of neuronal collagens.