MECP2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1887-Each-of-1 | In Stock | ₹ 48,282.50 |
PA1887 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,282.50
GST (18%): ₹ 8,690.85
Total Price: ₹ 56,973.35
Antigen
MECP2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Mecp2
Gene Alias
1500041B07Rik; AUTSX3; D630021H01Rik; DKFZp686A24160; Mbd5; MECP2; MeCp-2 protein; methyl CpG binding protein 2; methyl-CpG binding protein 2; methyl-CpG-binding protein 2; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT; testis tissue sperm-binding protein Li 41a; WBP10
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
17257, 29386, 4204
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P51608, Q00566, Q9Z2D6
Gene Symbols
Mecp2
Immunogen
Synthetic Peptide: M(1) V A G M L G L R E E K S E D(15) C
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-887 detects methyl CpG binding protein 2 (MeCP2) from human, mouse and rat tissues and cells
- PA1-887 has been successfully used in Western blot, IHC-P, immunofluorescence and immunoprecipitation procedures
- By Western blot, this antibody detects an ∽56 kDa protein representing MeCP2 from AtT20 cell extract
- PA1-887 immunizing peptide corresponds to amino acid residues 1-15 from mouse MeCP2
- This sequence is completely conserved in human MeCP2
- PA1-887 immunizing peptide (Cat
- # PEP-120) is available for use in neutralization and control experiments
- MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain
- MECP2 is capable of binding specifically to methylated DNA
- DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development
- MECP2 can also repress transcription from methylated gene promoters
- In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation
- MECP2 is dispensible in stem cells, but is essential for embryonic development
- MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.