PA1758
Nicastrin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1758-Each-of-1 | In Stock | ₹ 44,455.50 |
PA1758 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,455.50
GST (18%): ₹ 8,001.99
Total Price: ₹ 52,457.49
Antigen
Nicastrin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
NCSTN
Gene Alias
9430068N19Rik; AA727311; anterior pharynx-defective 2; Aph2; ATAG1874; D1Dau13e; Kiaa0253; mKIAA0253; NCSTN; Nct; Nicastrin; OTTHUMP00000031840; UNQ1874/PRO4317
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23385, 289231, 59287
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P57716, Q8CGU6, Q92542
Gene Symbols
NCSTN
Immunogen
Synthetic Peptide: C(688) I N A K A D V L F I A P R E P G A V S Y(708)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-758 detects nicastrin from human, mouse and rat samples
- PA1-758 has been successfully used in Western blot procedures
- By Western blot, this antibody detects an ∽110 kDa protein representing nicastrin
- PA1-758 immunizing peptide corresponds to amino acid residues 688-708 from human nicastrin
- There is a single amino acid substitution between the human and mouse sequence
- PA1-758 immunizing peptide (Cat
- # PEP-131) is available for use in neutralization and control experiments
- NCSTN (Nicastrin) is a gene that encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex
- The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly
- The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain
- Mutations in this gene are associated with familial acne inversa
- A pseudogene of this gene is present on chromosome 21.