PA1774
RPH3A Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1774-Each-of-1 | In Stock | ₹ 47,748.50 |
PA1774 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,748.50
GST (18%): ₹ 8,594.73
Total Price: ₹ 56,343.23
Antigen
RPH3A
Classification
Polyclonal
Conjugate
Unconjugated
Gene
RPH3A
Gene Alias
2900002P20Rik; AU022689; AW108370; Exophilin 1; Exophilin1; Exophilin-1; KIAA0985; rabphilin 3A; rabphilin 3A homolog; rabphilin-3A; RPH3A
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
171039, 19894
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P47708, P47709
Gene Symbols
RPH3A
Immunogen
Synthetic peptide corresponding to residues M(1) T D T V V N R W M Y P G D G P L Q(18) C of rat Rabphilin 3A.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-774 detects rabphilin 3A from rat tissues
- PA1-774 has been successfully used in Western blot procedures
- By Western blot, this antibody detects an ∽75 kDa protein representing rabphilin 3A from rat brain whole protein extract
- PA1-774 immunogen is a synthetic peptide corresponding to residues M(1) T D T V V N R W M Y P G D G P L Q(18) C of rat Rabphilin 3A
- This sequence is completely conserved between rat and mouse rabphilin 3A
- PA1-774 immunizing peptide (Cat
- # PEP-102) is available for use in neutralization and control experiments
- The carboxy-terminal of rabphilin-3A consists of two C2 domains, A and B, and the amino-terminal (residues 45-170) contains a cysteine-rich rich region with two zinc finger motifs
- Rabphilin-3A belongs to a family of other carboxyterminal type (C-type) tandem C2 proteins, which includes synaptotagmins and Doc2
- Rabphilin is expressed in neuroendocrine cells and co-localizes with Rab3A on synaptic vesicles and chromaffin granules
- Rabphilin-3A binds Rab3a/GTP/Mg+ within amino-terminal residues 45 and 170
- Rabphilin-3A binds calcium ions and phosphatidylinositol 4,5-bisphophate containing lipid vesicles within its C2 domains
- Rabphilin-3A is a positive regulator of calcium dependent exocytosis, while Rab3a is a negative regulator of exocytosis
- Although rabphilin-3A associates with Rab3a, they seem to influence exocytosis independently of each other
- Rabphilin-3A effects are likely mediated through interactions with an unknown factor that recognizes the Rab3 binding domain.