AANAT Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1762-Each-of-1 | In Stock | ₹ 44,455.50 |
PA1762 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,455.50
GST (18%): ₹ 8,001.99
Total Price: ₹ 52,457.49
Antigen
AANAT
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Aanat
Gene Alias
Aanat; AA-NAT; Aralkylamine N-acetyltransferase; arylakylamine N-acetyltransferase; Arylalkylamine N - acetyltransferase (Serotonin N - acetyltransferase); arylalkylamine N-acetyltransferase; DSPS; Nat-2; Nat4; Seretonin N-acetyltransferase; serotonin acetylase; Serotonin N-acetyltransferase; SNAT
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
25120
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
Q64666
Gene Symbols
Aanat
Immunogen
Synthetic Peptide: C(195) H T F L R R N S G C(205)
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-762 has successfully been used to detect serotonin N-AT in both WB and IF applications
- PA1-762 detects serotonin N-acetyltransferase (AA-NAT) from rat tissues
- PA1-762 has been successfully used in Western blot procedures
- By Western blot, this antibody detects an ∽23 kDa protein representing unphosphorylated and phosphorylated AA-NAT from rat pineal gland whole protein extract
- PA1-762 immunizing phosphopeptide (Cat
- # PEP-066) corresponds to carboxy-terminal amino acid residues 198-208 of rat AA-NAT
- Total anti-carboxy-terminal AA-NAT-specific IgG (Cat
- # PA1-762) was affinity purified on resin-coupled non-phosphopeptide (Cat
- # PEP-065)
- Phospho-specific carboxy-terminal IgG (Cat
- # PA1-763) was subsequently isolated on resin-coupled phosphopeptide (Cat
- # PEP-066)
- This sequence is completely conserved between rat and mouse AA-NAT protein
- Arylalkylamine N-Acetyltransferase (AANAT) is the penultimate enzyme is melatonin synthesis
- Hormonal melatonin has been implicated in sleep and circadian clock function
- Large changes in the abundance of AANAT are believed to be responsible for the large day/night rhythms in melatonin synthesis in the pineal gland and retina
- Most research shows that AANAT activity is regulated by controlling the steady-state levels of the protein
- Recent research, however, suggests that another mechanism may also play a role in controlling melatonin production without altering AANAT protein and activity
- This mechanism may explain the sudden physiological increase in circulating melatonin observed at the onset of the dark period in humans.