DNMT3B Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1884-Each-of-1 | In Stock | ₹ 47,570.50 |
PA1884 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,570.50
GST (18%): ₹ 8,562.69
Total Price: ₹ 56,133.19
Antigen
DNMT3B
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Dnmt3b
Gene Alias
DNA (cytosine-5-)-methyltransferase 3 beta; DNA (cytosine-5)-methyltransferase 3B; DNA methyltransferase 3 beta; DNA methyltransferase 3B; DNA methyltransferase HsaIIIB; DNA methyltransferase MmuIIIB; DNA MTase HsaIIIB; DNA MTase MmuIIIB; Dnmt3; DNMT3B; ICF; ICF1; M.HsaIIIB; m.MmuIIIB; MGC1090; MmuIIIB
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
13436, 1789
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
O88509, Q9UBC3
Gene Symbols
Dnmt3b
Immunogen
Synthetic peptide corresponding to the residues M(1) K G D S R H L N E E E G A(14) C of mouse DNMT3b
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-884 detects DNA methyltransferase 3 from human and mouse tissues and cells as well as recombinant human Dnmt3
- This antibody has been used to detect both recombinant and endogenous DNMT3b and recombinant DNMT3a
- PA1-884 has been successfully used in Immunohistochemistry (paraffin) and Western blot procedures
- By Western blot, this antibody detects DNMT3 from P19 nuclear extracts
- The PA1-884 immunogen is a synthetic peptide corresponding to residues 1-14 of mouse DNMT3b
- This sequence is 79% conserved between human and mouse
- PA1-884 immunizing peptide (Cat
- # PEP-117) is available for use in neutralization and control experiments
- CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation
- Studies in mice have demonstrated that DNA methylation is required for mammalian development
- This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation
- The protein localizes primarily to the nucleus and its expression is developmentally regulated
- Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome
- Six alternatively spliced transcript variants have been described
- The full length sequences of variants 4 and 5 have not been determined.