MBD1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1889-Each-of-1 | In Stock | ₹ 41,385.00 |
PA1889 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,385.00
GST (18%): ₹ 7,449.30
Total Price: ₹ 48,834.30
Antigen
MBD1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MBD1
Gene Alias
CXXC3; CXXC-type zinc finger protein 3; Mbd1; methyl-CpG binding domain protein 1; methyl-CpG binding domain protein 1 isoform PCM1; methyl-CpG-binding domain protein 1; Methyl-CpG-binding protein MBD1; PCM1; Protein containing methyl-CpG-binding domain 1; RFT; the regulator of fibroblast growth factor 2 (FGF-2) transcription
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
4152
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
Q9UIS9
Gene Symbols
MBD1
Immunogen
Synthetic Peptide: C R(593) S K D L K K P G A R K Q(605)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-889 detects human methyl CpG binding domain protein 1 (MBD1) recombinant protein
- PA1-889 has been successfully used in Western blot procedures
- By Western blot, this antibody detects an ∽83 kDa protein representing recombinant human MBD1
- PA1-889 immunizing peptide corresponds to amino acid residues 593-605 from human MBD1 protein
- PA1-889 immunizing peptide (Cat
- # PEP-130) is available for use in neutralization and control experiments
- Methyl-CpG-binding domain protein 1 (MBD1) is a member of a family of mammalian proteins that specifically bind methylated regions of DNA
- It is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides
- Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS)
- MBD1 acts as a transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1
- Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.