MAP4K3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA548695-Each-of-1 | In Stock | ₹ 46,057.50 |
PA548695 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,057.50
GST (18%): ₹ 8,290.35
Total Price: ₹ 54,347.85
Antigen
MAP4K3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MAP4K3
Gene Alias
4833416M01Rik; 4833416M07Rik; 9530052P13Rik; germinal center kinase-like kinase; germinal center kinase-related protein kinase; GLK; MAP4K3; MAPK/ERK kinase kinase kinase 3; MAPKKKK3; MEK kinase kinase 3; MEKKK 3; MEKKK3; mitogen activated protein kinase kinase kinase kinase 3; mitogen-activated protein kinase kinase kinase kinase 3; RAB8IPL1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography, Protein A
Regulatory Status
RUO
Gene ID (Entrez)
225028, 8491
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
Q8IVH8, Q99JP0
Gene Symbols
MAP4K3
Immunogen
KLH conjugated synthetic peptide between 501-529 amino acids from the Central region of mouse Map4k3.
Quantity
400 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Predicted to react with rat based on sequence homology
- MAP4K3 (also known as GLK) is a member of the STE20 family of serine/threonine protein kinases and contains N-terminal catalytic domain and C-terminal regulatory domain
- MAP4K3 is upstream of the MEKK1 target and is stimulated by UV radiation and TNF-alpha and can lead to the activation of the JNK signaling pathway
- MAP4K3 can directly activate PKC-T, during TCR signaling and people with systemic lupus erythematosus show considerable enhanced MAP4K3 expression and activation of PKC-T, and the kinase IKK in T cells
- MAP4K3 can act as a pro-apoptotic kinase which orchestrates activation of BAX via the concerted posttranscriptional modulation of PUMA, BAD, and BIM
- The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha
- The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway
- Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase 1 (MEKK1)
- MAP4K3 previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase 3 (MAP4K3).