PA549835
SGOL1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA549835-Each-of-1 | In Stock | ₹ 46,502.50 |
PA549835 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
SGOL1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SGO1
Gene Alias
3300001M08Rik; C81037; CAID; hSgo1; NY-BR-85; serologically defined breast cancer antigen NY-BR-85; SGO; Sgo1; Sgol1; Shugoshin 1; shugoshin 1A protein; shugoshin 1AB protein; shugoshin 1CD protein; shugoshin 1EF protein; shugoshin 1GH protein; shugoshin 1KL protein; shugoshin-like 1; shugoshin-like 1 (S. pombe)
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
151648
Content And Storage
-20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q5FBB7
Gene Symbols
SGO1
Immunogen
Synthesized peptide derived from internal of human SGOL1.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The antibody detects endogenous levels of total SGOL1 protein
- The protein encoded by this gene is a member of the shugoshin family of proteins
- This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit
- Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest
- Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase
- An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles
- Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life
- Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence
- Pseudogenes of this gene have been found on chromosomes 1 and 7
- Alternative splicing results in multiple transcript variants.