SPIN2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA550266-Each-of-1 | In Stock | ₹ 48,104.50 |
PA550266 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,104.50
GST (18%): ₹ 8,658.81
Total Price: ₹ 56,763.31
Antigen
SPIN2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SPIN2B
Gene Alias
BC068162; dJ323P24.2; Spin2; SPIN-2; SPIN2_duplicate; SPIN2B; SPIN-2B; Spin2c; SPIN-2C; Spindlin 2B; spindlin family member 2B; spindlin family, member 2; spindlin family, member 2 duplicate; spindlin family, member 2B; spindlin family, member 2C; spindlin-2; spindlin-2B; Spindlin-2C; spindlin-like protein 2; spindlin-like protein 2B; Spindlin-like protein 2C; TDRD26; telomeric SPIN2 copy
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
278240, 474343
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1.1 mg/mL
Formulation
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
Q6NVE3, Q9BPZ2
Gene Symbols
SPIN2B, Spin2c
Immunogen
Full length fusion protein of Human SPIN2B
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The antibody detects endogenous levels of total SPIN2 protein
- Human SPIN2 expressed by 2 IL3-dependent murine myeloid cell lines was moderately antiapoptotic following IL3 removal, but it was unable to block apoptosis induced by the chemotherapy agent doxorubicin
- On the contrary, SPIN2-expressing cells were more sensitive to doxorubicin-mediated cell death
- Also, SPIN2 did not combat the proapoptotic effects of Fas ligand stimulation in the Jurkat human T-cell line
- Deletion of the C-terminal amino acids of SPIN2 diminished its antiapoptotic activity
- In the murine myeloid cells, SPIN2 overexpression increased the cell number doubling times and slowed their rate of growth
- There was also an increased percentage of cells in G2/M, which was more pronounced following IL3 withdrawal.