PFKL Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA551035-Each-of-1 | In Stock | ₹ 46,413.50 |
PA551035 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Antigen
PFKL
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PFKL
Gene Alias
6-phosphofructokinase type B; 6-phosphofructokinase, liver type; AA407869; ATP-dependent 6-phosphofructokinase, liver type; ATP-dependent 6-phosphofructokinase, liver type {ECO:0000255; ATP-PFK; ATP-PFK {ECO:0000255; EC 2.7.1.11; HAMAP-Rule:MF_03184}; K6PL; liver-type 1-phosphofructokinase; Pfkb; PFK-B; Pfkl; Pfk-l; Phosphofructo-1-kinase isozyme B; phosphofructokinase 1; phosphofructokinase, liver; phosphofructokinase, liver type; phosphofructokinase, liver, B-type; phosphohexokinase; phosphohexokinase {ECO:0000255
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
18641, 25741, 5211
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry, Western Blot, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P12382, P17858, P30835
Gene Symbols
PFKL
Immunogen
Synthesized peptide derived from the C-terminal region of human PFK-B.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PFKL Polyclonal Antibody detects endogenous levels of PFKL protein
- Phosphofructokinase (PFK), a major regulatory enzyme in all cells of the body, catalyzes the metabolism of sugar, and thereby is pivotal in the production of energy to maintain normal cell function
- In human there are three structural loci controlling PFK: M (muscle), L (liver), and P (platelet) type subunits, which are variably expressed in different tissues; human diploid fibroblasts and leukocytes express all three genes
- PFK, a tetramer formed by the random association of the products of two separate gene loci to form the five possible tetramers
- PFKs of muscle and liver are homotetramers of the M and L subunits, respectively
- Red cells have all five isozymes: M4, M3L, M2L2, ML3, and L4
- PFK is an allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate
- PFK catalyzes the key controlling step of glycolytic pathway
- PFK deficiency can present as mild to life-threatening episodic illness
- A hallmark sign of this disease is intermittent dark urine, with the color of the urine ranging from orange to dark coffee-brown, which commonly develops following strenuous exercise
- The mean red cell PFK is elevated in persons with Down syndrome.