PI711355
IRF8 Recombinant Polyclonal Antibody (24HCLC), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PI711355-Each-of-1 | In Stock | ₹ 54,112.00 |
PI711355 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 54,112.00
GST (18%): ₹ 9,740.16
Total Price: ₹ 63,852.16
Antigen
IRF8
Classification
Recombinant Polyclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q02556
Gene Symbols
Irf8
Immunogen
Peptides corresponding to Human IRF8 (aa 261-277, 411-426)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry
Clone
24HCLC
Conjugate
Unconjugated
Gene
Irf8
Gene Alias
AI893568; H-ICSBP; Icsbp; Icsbp1; IMD32A; IMD32B; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; Irf8; IRF-8; Myls; transcription factor ICSBP
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
3394
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- This antibody is predicted to react with Monkey, Dog and Rabbit Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific
- They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody
- While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains
- The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production
- IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor
- It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes
- IRF8 plays a negative regulatory role in cells of the immune system
- It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells
- This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes
- Mutations in the gene can result in immunodeficiencey 32A and 32B.