INSR Recombinant Rabbit Monoclonal Antibody (6H23L15), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PI701049-Each-of-1 | In Stock | ₹ 45,434.50 |
PI701049 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,434.50
GST (18%): ₹ 8,178.21
Total Price: ₹ 53,612.71
Antigen
INSR
Classification
Recombinant Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
P06213
Gene Symbols
INSR
Immunogen
Recombinant protein corresponding to amino acids 1283–1382 of human insulin receptor
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
6H23L15
Conjugate
Unconjugated
Gene
INSR
Gene Alias
4932439J01Rik; CD 220; CD220; CD220 antigen; CD220 beta; CD221; D630014A15Rik; HHF 5; HHF5; IGF-I receptor; INSR; Insulin receptor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR 1; IR beta; IR1; IR-1; IR-A; IR-B
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
3643
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- This antibody is predicted to react with mouse based on sequence homology
- Intact IgG appears on a non-reducing gel as ∽150 kDa band and upon reduction generating a ∽25 kDa light chain band and a ∽50 kDa heavy chain
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- INSR is a receptor tyrosine kinase
- Binding of insulin to the extracellular domain of INSR stimulates glucose uptake
- INSR and IGF-1 receptors share major structural and functional similarity
- The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR
- In humans, the INSR gene is located on chromosome 19
- Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.