TGF beta-1 Monoclonal Antibody (TB21), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA134093-Each-of-1 | In Stock | ₹ 79,922.00 |
PIMA134093 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 79,922.00
GST (18%): ₹ 14,385.96
Total Price: ₹ 94,307.96
Antigen
TGF beta-1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
P01137, P04202, P17246, P18341, P50414
Gene Symbols
Tgfb1
Immunogen
Human Transforming Growth Factor Beta 1 from platelets
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Bovine, Human, Mink, Mouse, Mustelid, Ovine, Rabbit, Rat
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone
TB21
Conjugate
Unconjugated
Gene
Tgfb1
Gene Alias
CED; cytokine; DPD1; LAP; Latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; TGF b; TGF b 1; TGF beta; tgf beta 1; tgf beta1; TGF beta-1; TGF beta-1 protein; TGF β; TGF β 1; TGF β1; Tgfb; TGFB1; TGF-B1; Tgfb-1; TGFbeta; TGF-beta 1; TGF-beta 1 protein; TGFbeta1; TGF-beta1; TGF-beta-1; TGFβ1; Transforming growth factor; transforming growth factor b1; transforming growth factor beta; transforming growth factor beta 1; transforming growth factor beta-1; Transforming growth factor beta-1 proprotein; transforming growth factor beta-1 proprotein; transforming growth factor beta-1; transforming growth factor β1; transforming growth factor, beta 1; transforming growth factor, beta 1 (Camurati-Engelmann disease); transforming growth factor, beta-1; transforming growth factor-beta 1; transforming growth factor-beta I; transforming growth factor-beta-1; transforming growth factor-beta-1 precursor; unnamed protein product
Host Species
Mouse
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
100008645, 21803, 282089, 443417, 59086, 7040
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- MA1-34093 detects TGF beta from human, rat and sheep samples
- TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues
- Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain
- Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins
- Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP
- TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types
- Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors
- TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer
- The mature peptide may also form heterodimers with other TGF beta family members
- The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.