IGF1 Monoclonal Antibody (7973), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA518035-Each-of-1 | In Stock | ₹ 59,897.00 |
PIMA518035 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 59,897.00
GST (18%): ₹ 10,781.46
Total Price: ₹ 70,678.46
Antigen
IGF1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
P05017, P05019, P08025
Gene Symbols
IGF1
Immunogen
Human IGF-1 conjugated to carrier protein
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1
Applications
ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Radioimmune Assays (RIA)
Clone
7973
Conjugate
Unconjugated
Gene
IGF1
Gene Alias
C730016P09Rik; class 1 insulin-like growth factor I preproprotein; class 2 insulin-like growth factor I preproprotein; H-IGF-1; IBP1; IGF; IGF1; Igf-1; IGF1A; IGFI; Igf-I; IGFIa; IGF-IA; IGF-IB; insulin growth factor-1; Insulin like growth factor; insulin like growth factor 1; insulin-like growth factor 1; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor I; insulin-like growth factor I (somatomedin C); insulin-like growth factor IB; mechano growth factor; MGF; M-IGF-1; OTTHUMP00000195084; prepro-IGF-I; prepro-insulin-like growth factor I; R-IGF-1; somatomedin; Somatomedin C; Somatomedin-C
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
16000, 24482, 3479
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- IGF1 (Insulin-like growth factor-1) is structurally and functionally related to insulin but has a much higher growth-promoting activity
- A variety of cellular responses are induced by IGF1, including cell proliferation, differentiation, migration, and survival
- Further, IGF1 is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types in muscle, bone, and cartilage tissue
- IGF1 stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regards to enhancing glucose uptake
- In circulation, IGFs are predominantly bound to binding proteins (IGFBPs) which prolong the half-life of the IGFs and play a role in delivering them to target tissues
- IGF-I is known as one of the most potent activators of the AKT signaling pathway which is known to be a stimulator of proliferation and an inhibitor of programmed cell death
- Moreover, mature human IGF-I is 100% homologous with bovine and porcine proteins
- Low levels of IGF1 have been linked to Alzheimer's disease
- IGF1 is processed from a precursor, bound by a specific receptor, and secreted
- Defects in the IGF1 gene are a cause of insulin-like growth factor 1 deficiency and several transcript variants encoding different isoforms have been found.