CHK2 Monoclonal Antibody (2CHK01 (DCS-293)), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA511940-Each-of-1 | In Stock | ₹ 55,892.00 |
PIMA511940 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 55,892.00
GST (18%): ₹ 10,060.56
Total Price: ₹ 65,952.56
Antigen
CHK2
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene Accession No.
O96017
Gene Symbols
Chek2
Immunogen
Recombinant Chk2 protein
Quantity
500 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone
2CHK01 (DCS-293)
Conjugate
Unconjugated
Gene
Chek2
Gene Alias
CDS1; cds1 homolog; Checkpoint kinase 2; Checkpoint like protein CHK2; checkpoint-like protein CHK2; Chek2; Chk2; Chk2 (phospho T68); Chk2 (pThr68); CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe); Chk2 phospho; Chk2 phospho T68; del9; EC 2.7.11.1; hCds1; HuCds 1; HuCds1; kinase Chk2; LFS2; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199064; OTTHUMP00000199115; OTTHUMP00000199116; phospho Chk2 (T68); phospho Thr68 Chk2; PP1425; protein kinase Chk2; Rad53; Rad53 homolog; RP11-436C9.1; Serine/threonine protein kinase Chk2; serine/threonine-protein kinase Chk2
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
11200
Content And Storage
4° C
Form
Liquid
Related Products
Description
- MA5-11940 targets Chk2 in immunofluorescence, immunoprecipiation, and Western blot applications and shows reactivity with Human samples
- The antibody does not react with Chk1
- The MA5-11940 immunogen is recombinant Chk2 protein
- CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway
- A mutation in CHK2 has been linked to cancer
- CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins
- In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage
- Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53
- Also, mutations in CHK2 are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.