Bax Monoclonal Antibody (2D2), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA513994-Each-of-1 | In Stock | ₹ 49,884.50 |
PIMA513994 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,884.50
GST (18%): ₹ 8,979.21
Total Price: ₹ 58,863.71
Antigen
Bax
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene Accession No.
Q07812
Gene Symbols
BAX
Immunogen
A synthetic peptide, aa 3-16 (Cys-GSGEQPRGGGPTSS) of human bax protein. This amino acid sequence is NOT shared by mouse and rat bax protein.
Quantity
500 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
2D2
Conjugate
Unconjugated
Gene
BAX
Gene Alias
apoptosis regulator BAX; Apoptosis regulator Bcl-X; Bax; Bax zeta; BAX-ALPHA; Bax-alpha protein; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; BCL2 associated X protein; BCL2 associated X, apoptosis regulator; BCL2 like 1; BCL2-associated protein; Bcl-2-associated protein Bax; Bcl2-associated protein Bax; Bcl-2-associated X protein; BCL2-associated X protein; BCL2-associated X protein omega; BCL2L; BCL2L1; Bcl2-L-1; BCL2L4; Bcl2-L-4; BCL2-like 1; bcl-2-like protein 1; Bcl-2-like protein 4; BCLX; Bcl-X; BCL-XL/S; PPP1R52; protein phosphatase 1, regulatory subunit 52
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
581
Content And Storage
4° C
Form
Liquid
Related Products
Description
- MA5-13994 targets Bax in IF, IHC (P), and WB applications and shows reactivity with Human samples
- The MA5-13994 immunogen is a synthetic peptide, aa 3-16 (Cys-GSGEQPRGGGPTSS) of human bax protein
- This amino acid sequence is NOT shared by mouse and rat bax protein
- BAX is a members of the Bcl-2 Family and plays an important role in regulation of apoptosis
- Whereas Bcl-2 is commonly regarded as an anti-apoptotic protein, BAX is considered to have a pro-apoptotic function
- Regulation of apoptosis is supposed to involve both homo- and heterodimerization of different isoforms of BAX and Bcl-2
- The Bax gene encodes different isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa), whereas both isoforms contain the BH1, BH2 and BH3 domains, Bax beta has a unique carboxyl terminus and does not contain a hydrophobic transmembrane domain
- Bcl-2 is also expressed in different Isoforms
- Bcl-2 beta differs in the 3' UTR and coding region compared to variant alpha
- Bcl-2 beta is shorter (22 kDa) and has a distinct C-terminus compared to Bcl-2 alpha (26 kDa)
- BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis
- Overexpression of BAX functions to promote cell death
- BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.