Lamin A (Cleaved Asp230) Monoclonal Antibody (C.69.9), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515211-Each-of-1 | In Stock | ₹ 48,994.50 |
PIMA515211 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,994.50
GST (18%): ₹ 8,819.01
Total Price: ₹ 57,813.51
Antigen
Lamin A (Cleaved Asp230)
Classification
Monoclonal
Concentration
1 μg/mL
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.
P02545, P48678, P48679
Gene Symbols
LMNA
Immunogen
Synthetic peptide corresponding to amino-terminal residues surrounding Asp230 of human lamin A
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1
Applications
Immunocytochemistry, Western Blot
Clone
C.69.9
Conjugate
Unconjugated
Gene
LMNA
Gene Alias
70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A; lamin A/C; lamin A/C-like 1; lamin C; lamin C2; lamin-A/C; LDP1; LFP; LGMD1B; Lmn1; LMNA; LMNC; LMNL1; OTTHUMP00000015843; OTTHUMP00000015846; OTTHUMP00000015847; Prelamin-A/C; PRO1; Renal carcinoma antigen NY-REN-32
Host Species
Mouse
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16905, 4000, 60374
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- It is not recommended to aliquot this antibody
- This antibody is not cross-reactive with full length lamin A or C
- The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane
- The lamin family of proteins make up the matrix and are highly conserved in evolution
- During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated
- Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression
- Vertebrate lamins consist of two types, A and B
- Through alternate splicing, this gene encodes three type A lamin isoforms
- Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.