MLH1 Monoclonal Antibody (4C9C7), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515431-Each-of-1 | In Stock | ₹ 55,714.00 |
PIMA515431 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 55,714.00
GST (18%): ₹ 10,028.52
Total Price: ₹ 65,742.52
Antigen
MLH1
Classification
Monoclonal
Concentration
Conc. Not Determined
Formulation
ascites with 0.03% sodium azide
Gene Accession No.
P40692
Gene Symbols
Mlh1
Immunogen
Purified recombinant fragment of MLH1 (aa381-483) expressed in E. Coli.
Regulatory Status
RUO
Gene ID (Entrez)
4292
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot
Clone
4C9C7
Conjugate
Unconjugated
Gene
Mlh1
Gene Alias
1110035C23Rik; AI317206; AI325952; AI561766; COCA2; colon cancer, nonpolyposis type 2; DNA mismatch repair protein Mlh1; DNA mismatch repair protein Mlh1-like protein; FCC2; hMLH1; HNPCC; HNPCC2; I79_014127; MGC5172; mismatch repair protein 1; MLH1; MLH-1; mutL homolog 1; mutL homolog 1 (E. coli); mutL homolog 1, colon cancer, nonpolyposis type 2; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); mutL protein homolog 1
Host Species
Mouse
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Non-human Primate
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- MA5-15431 targets MLH1 in indirect ELISA, IF, IHC, and WB applications and shows reactivity with Human and Non-human primate samples
- The MA5-15431 immunogen is purified recombinant fragment of MLH1 (aa381-483) expressed in E
- Coli.<br>
- MA5-15431 detects MLH1 which has a predicted molecular weight of approximately 85kDa
- MLH1 is a DNA mismatch repair protein
- The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time
- An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI)
- These defects in DNA repair pathways have been related to human carcinogenesis
- The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC)
- MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process
- It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.