WNT1 Monoclonal Antibody (10C8), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515544-Each-of-1 | In Stock | ₹ 52,287.50 |
PIMA515544 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,287.50
GST (18%): ₹ 9,411.75
Total Price: ₹ 61,699.25
Antigen
WNT1
Classification
Monoclonal
Concentration
Conc. Not Determined
Formulation
ascites with 0.03% sodium azide
Gene Accession No.
P04426, P04628
Gene Symbols
WNT1
Immunogen
Purified recombinant fragment of WNT1 expressed in E. Coli.
Regulatory Status
RUO
Gene ID (Entrez)
22408, 7471
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot
Clone
10C8
Conjugate
Unconjugated
Gene
WNT1
Gene Alias
BMND16; INT1; Int-1; murine mammary tumor virus integration site; OI15; Proto-oncogene Int-1; proto-oncogene Int-1 homolog; proto-oncogene protein Wnt-1; proto-oncogene Wnt-1; sw; swaying; wingless-related MMTV integration site 1; Wingless-type MMTV integration site 1 homolog; Wingless-type MMTV integration site 1, homolog; wingless-type MMTV integration site family member 1; wingless-type MMTV integration site family, member 1; wingless-type MMTV integration site family, member 1 (oncogene INT1); Wnt family member 1; Wnt1; Wnt-1
Host Species
Mouse
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- MA5-15544 targets WNT1 in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human and mouse samples
- The MA5-15544 immunogen is purified recombinant fragment of WNT1 expressed in E
- Coli
- MA5-15544 detects WNT1 which has a predicted molecular weight of approximately 41kDa
- Wnt proteins constitute a family of secreted glyocoproteins that activate signal transduction pathways to mediate tissue homeostasis, cell fate, cell proliferation, and self-renewal
- The canonical signaling pathway is initiated upon Wnt binding to a Frizzled family receptor and an LRP5/LRP6 coreceptor, which leads to activation of the beta-catenin cascade
- Non-canonical Wnt signals are activated by binding to a Frizzled family receptor and ROR2 coreceptor
- Extensive research has shown that deregulation of these pathways or its components can lead to cancer
- Human Wnt-1 is encoded as a 370 amino acid precursor that, upon secretion, is cleaved into a 343 amino acid (42 kDa) mature form
- At the amino acid level, mature human Wnt-1 is approximately 99% identical to mature mouse Wnt-1
- Depending on the tissue, Wnt-1 can activate the canonical and non-canonical signaling pathways
- Studies have demonstrated its involvement in a variety of functions, including embryonic development and carcinogenesis
- Wnt-1 signaling can also induce the phosphorylation and subsequent degradation of c-Myb.