PIMA515743
APAF1 Monoclonal Antibody (2E10), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515743-Each-of-1 | In Stock | ₹ 47,125.50 |
PIMA515743 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,125.50
GST (18%): ₹ 8,482.59
Total Price: ₹ 55,608.09
Antigen
APAF1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
O14727, O88879, Q9EPV5
Gene Symbols
APAF1
Immunogen
A peptide corresponding to amino acids near the carboxy terminus of human Apaf1.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1
Applications
Immunohistochemistry, Western Blot
Clone
2E10
Conjugate
Unconjugated
Gene
APAF1
Gene Alias
6230400I06Rik; APAF1; APAF-1; Apaf1l; apoptotic peptidase activating factor 1; apoptotic protease activating factor 1; apoptotic protease-activating factor 1; CED4; DKFZp781B1145; fog; forebrain overgrowth; KIAA0413; mKIAA0413
Host Species
Mouse
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
11783, 317, 78963
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- In Western blot applications, this antibody detects a band at ∽130kDa
- A suggested positive control is K562 cell lysate
- APAF1 gene encodes a cytoplasmic protein that initiates apoptosis
- This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC)
- Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome
- The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form
- Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis
- Alternative splicing results in several transcript variants encoding different isoforms.