PIMA515783
IRAK1 Monoclonal Antibody (8F1A7), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515783-Each-of-1 | In Stock | ₹ 50,685.50 |
PIMA515783 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,685.50
GST (18%): ₹ 9,123.39
Total Price: ₹ 59,808.89
Antigen
IRAK1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
P51617, Q62406
Gene Symbols
Irak1
Immunogen
Recombinant protein corresponding to amino acids 618 - 712 of human IRAK.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1
Applications
Immunohistochemistry, Western Blot
Clone
8F1A7
Conjugate
Unconjugated
Gene
Irak1
Gene Alias
AA408924; Il1rak; interleukin 1 receptor associated kinase 1; interleukin-1 receptor-associated kinase 1; interleukin-1 receptor-associated kinase-1; IRAK; Irak1; IRAK-1; IRAK1-S; mPLK; pelle; Pelle homolog; pelle-like protein kinase; Plpk; RGD1563841
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
16179, 363520, 3654
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- A suggested positive control is IRAK recombinant protein
- IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways
- It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation
- IRAK's association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation
- Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation
- IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus
- This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.