PIMA515744
APAF1 Monoclonal Antibody (5E11), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515744-Each-of-1 | In Stock | ₹ 47,036.50 |
PIMA515744 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,036.50
GST (18%): ₹ 8,466.57
Total Price: ₹ 55,503.07
Antigen
APAF1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
O14727, O88879, Q9EPV5
Gene Symbols
APAF1
Immunogen
A peptide corresponding to amino acids near the carboxy terminus of human Apaf1.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1 κ
Applications
Immunohistochemistry
Clone
5E11
Conjugate
Unconjugated
Gene
APAF1
Gene Alias
6230400I06Rik; APAF1; APAF-1; Apaf1l; apoptotic peptidase activating factor 1; apoptotic protease activating factor 1; apoptotic protease-activating factor 1; CED4; DKFZp781B1145; fog; forebrain overgrowth; KIAA0413; mKIAA0413
Host Species
Mouse
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
11783, 317, 78963
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- A suggested positive control is K562 cell lysate
- APAF1 gene encodes a cytoplasmic protein that initiates apoptosis
- This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC)
- Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome
- The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form
- Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis
- Alternative splicing results in several transcript variants encoding different isoforms.