FALZ Monoclonal Antibody (2F10), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515842-Each-of-1 | In Stock | ₹ 50,151.50 |
PIMA515842 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,151.50
GST (18%): ₹ 9,027.27
Total Price: ₹ 59,178.77
Antigen
FALZ
Classification
Monoclonal
Concentration
Conc. Not Determined
Formulation
ascites with 0.03% sodium azide
Gene Accession No.
Q12830
Gene Symbols
BPTF
Immunogen
Purified recombinant fragment of human BPTF expressed in E. Coli.
Regulatory Status
RUO
Gene ID (Entrez)
2186
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
ELISA, Immunocytochemistry, Western Blot
Clone
2F10
Conjugate
Unconjugated
Gene
BPTF
Gene Alias
9430093H17Rik; BPTF; bromodomain and PHD domain transcription factor; bromodomain and PHD finger-containing transcription factor; bromodomain PHD finger transcription factor; FAC1; FALZ; fetal Alz-50 clone 1 protein; fetal Alz-50 reactive clone 1; fetal Alzheimer antigen; nucleosome remodeling factor, large subunit; nucleosome-remodeling factor subunit BPTF; NURF301
Host Species
Mouse
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2b
Related Products
Description
- MA5-15842 has been tested in indirect ELISA
- BPTF (bromodomain and PHD domain transcription factor) is the largest subunit of the ATP-dependent chromatin-remodelling complex, NURF (nucleosome remodelling factor)
- NURF catalyses ATP-dependent nucleosome sliding and facilitates transcription
- BPTF recognises histone H3 tails that are tri-methylated at K4, which marks the transcriptional start site of the vast majority of transcriptionally active genes
- BPTF also exhibits some binding to H3 di-methylated at K4
- BPTF plays a key role in the development of early mouse embryos, possibly through regulation of the Smad pathway of transcription factors
- While BPTF is expressed in low levels in the adult brain and spinal cord, it is expressed in higher levels in the brain in neurodegenerative diseases
- It is present in a subset of amyloid-containing plaques in the brains of patients suffering from Alzheimer's disease
- Abundantly expressed in the fetal brain
- Present throughout the gray and white matter of the developing spinal cord at 18-22 gestational weeks
- Expressed at low levels in adult brain and spinal cord and reexpressed in neurodegenerative diseases (at protein level).Tissue specificity: Ubiquitously expressed, with highest levels in testis
- Present in kidney, liver and brain
- In the brain, highest levels are found in motor cortex (at protein level).