CD206 Monoclonal Antibody (MR5D3), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA516871-Each-of-1 | In Stock | ₹ 46,413.50 |
PIMA516871 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Antigen
CD206
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
Q61830
Gene Symbols
Mrc1
Immunogen
Chimaeric CRD4-7-Fc protein.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation
Clone
MR5D3
Conjugate
Unconjugated
Gene
Mrc1
Gene Alias
AW259686; bA541I19.1; CD206; CELE_Y39A3CR.4; CLEC13D; CLEC13DL; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; ddp-1; hMR; Human mannose receptor; macrophage mannose receptor 1; Macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1; mannose receptor, C type 1-like 1; Mitochondrial import inner membrane translocase subunit Tim8; MMR; MR; MRC1; MRC1L1; tim-8; Y39A3CR.4
Host Species
Rat
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
17533
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- CD206 is expressed weakly at the cell surface
- Staining may be increased following membrane permeabilization
- For FACS analysis, use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL
- Rat anti mouse CD206 antibody, clone MR5D3 recognizes the mouse mannose receptor, a approximately 175 kDa type 1 membrane glycoprotein that is also known as CD206
- Rat anti mouse CD206 antibody, clone MR5D3 recognizes the mouse mannose receptor, a approximately 175 kDa type 1 membrane glycoprotein that is also known as CD206
- CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors
- CD206 is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells and sperm cells
- CD206 is thought to play a role in the innate and adaptive immune response
- CD206 is also expressed on microglia and mato cells of the brain but not astrocytes or neurons
- CD206 also mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta)
- While the normal role of CD206 is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Amyloid beta deposition in Alzheimer's disease (AD)
- CD206’s gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing
- The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs)
- The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms
- CD206 has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis
- The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages
- Other diseases associated with CD206 dysfunction include leprosy and Gaucher’s Disease.