PIMA518086
CDH11 Monoclonal Antibody (16A6), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA518086-Each-of-1 | In Stock | ₹ 50,507.50 |
PIMA518086 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,507.50
GST (18%): ₹ 9,091.35
Total Price: ₹ 59,598.85
Antigen
CDH11
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1% sodium azide
Gene Accession No.
P55287
Gene Symbols
CDH11
Immunogen
Extracellular domain of human cadherin-11 fused to maltose binding protein
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Immunoprecipitation, Western Blot
Clone
16A6
Conjugate
Unconjugated
Gene
CDH11
Gene Alias
CAD11; Cad-11; Cadherin; cadherin 11; cadherin 11, type 2, OB-cadherin (osteoblast); cadherin-11; Cdh11; CDHOB; OB; OB Cadherin; OB-cadherin; OSF-4; Osteoblast cadherin; osteoblast-cadherin
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
1009
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion
- All cadherins are single-pass transmembrane proteins with a variable number of 110 amino acid extracellular cadherin (EC) domains
- Classical cadherins contain five large N-terminal EC domains, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain
- Based on amino acid alignment, classical cadherins are divided into type I and type II subgroups
- Type I cadherins, including cadherins E (epithelial), N (neural), P (placental), and R (retinal) cadherin differ from type I cadherins in their specific amino acid sequences
- Type II cadherins include human cadherin-5, -6, -8, -11, and -12
- Type II cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins
- Cadherin-11 (OB-Cadherin) is a marker of the loosely connected and migratory cellular elements of the mesenchyme
- Strong expression of Cadherin-11 has been noted in brain, spinal cord, bone marrow and bone cells, and is regulated in human endometrial glandular epithelial and stromal cells
- Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance
- A variant Cadherin-11 gene (variant form) encodes a truncated protein with an unusual cytoplasmic domain not present in other cadherins
- The variant protein is generated by alternative splicing, utilizing a 179 bp intronic sequence
- Recently, Cadherin-11 mRNA and protein were found to be expressed in most invasive breast cancer cell lines tested but not in non-invasive cell lines, suggesting that Cadherin-11 may be a marker for aggressive, invasive tumor subsets.