PIMA527491
RGMA Monoclonal Antibody (OTI4G8), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA527491-Each-of-1 | In Stock | ₹ 52,198.50 |
PIMA527491 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,198.50
GST (18%): ₹ 9,395.73
Total Price: ₹ 61,594.23
Antigen
RGMA
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q96B86
Gene Symbols
RGMA
Immunogen
Human recombinant protein fragment corresponding to amino acids 169-424 of RGMA produced in E.coli
Quantity
100μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2a
Applications
Immunohistochemistry (Paraffin)
Clone
OTI4G8
Conjugate
Unconjugated
Gene
RGMA
Gene Alias
BC059072; C230063O06; repulsive guidance molecule; repulsive guidance molecule A; repulsive guidance molecule family member a; RGM; RGM domain family member A; RGM domain family, member A; RGMA
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
56963
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system
- Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses
- Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition
- Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway
- It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.