CD107b (LAMP-2) Recombinant Rabbit Monoclonal Antibody (SA46-01), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA531970-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA531970 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
CD107b (LAMP-2)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P13473, P17046, P17047
Gene Symbols
LAMP2
Immunogen
Synthetic peptide within Human LAMP2a aa 361-410
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry, Western Blot
Clone
SA46-01
Conjugate
Unconjugated
Gene
LAMP2
Gene Alias
CD107 antigen-like family member B, CD107b, EGK_20887, Igp96, Lamp II, LAMP2, LAMP-2, LAMP-2 Isoform 2A, LAMP-2 Variant A, Lamp-2a, Lamp-2b, Lamp-2c, LAMPB, LGP110, LGP-110, LGP-96, LGP-B, lysosomal associated membrane protein 2, lysosomal membrane glycoprotein 2, lysosomal membrane glycoprotein type B, lysosomal-associated membrane protein 2, lysosome-associated membrane glycoprotein 2, lysosome-associated membrane protein 2, Mac3, RP23-193O17.2
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
16784, 24944, 3920
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins
- LAMP2 provides selectins with carbohydrate ligands, and may play a role in tumor cell metastasis, and have a function in the protection, maintenance, and adhesion of the lysosome
- Prior to posttranslational modification, LAMP2 is approximately 46 kDa polypeptide
- Mature, functional LAMP2 is extensively glycosylated with a variety of different N-linked and O-linked oligosaccharides with a total molecular weight of about 100-130 kDa
- LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail
- LAMP2 is used to monitor a very selective form of autophagy called chaperone-mediated autophagy
- LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail
- The LAMP protein has 3 variant forms: LAMP-2A, -2B, and 2C
- LAMP2, together with CD107a/LAMP-1, is a major constituent of lysosomal membrane
- The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, and LAMP2 is an important regulator in successful phagosomal maturation
- LAMP2 deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danon’s disease).