PCNA Recombinant Rabbit Monoclonal Antibody (SY12-07), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532051-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532051 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
PCNA
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P04961, P12004, P17918
Gene Symbols
Pcna
Immunogen
Synthetic peptide within Human PCNA aa 88-137
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SY12-07
Conjugate
Unconjugated
Gene
Pcna
Gene Alias
ATLD2, cb16, Cyclin, DNA polymerase delta auxiliary protein, etID36690.10, fa28e03, fb36g03, HGCN8729, hypothetical protein LOC515499, MGC8367, Pcna, pcna protein, Pcna/cyclin, PCNAR, POL30, Proliferating cell nuclear antigen, wu:fa28e03, wu:fb36g03, YBR0811, YBR088C
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
18538, 25737, 5111
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- PCNA (polymerase delta auxiliary protein) is essential for DNA replication and is involved in DNA excision and mismatch repair pathways
- PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT)
- PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumor tissue (i.e
- relevant to prognosis)
- PCNA is a marker for cells in early G1 phase and S phase of the cell cycle
- PCNA is found in the nucleus and is a cofactor of DNA polymerase delta, and acts as a homotrimer and helps increase the processing of leading strand synthesis during DNA replication
- In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway
- Two transcript variants encoding the same protein have been found for PCNA
- Pseudogenes of PCNA have been described on chromosome 4 and on the X chromosome.