Calnexin Recombinant Rabbit Monoclonal Antibody (SN20-54), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532332-Each-of-1 | In Stock | ₹ 47,125.50 |
PIMA532332 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,125.50
GST (18%): ₹ 8,482.59
Total Price: ₹ 55,608.09
Antigen
Calnexin
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P27824, P35565
Gene Symbols
CANX
Immunogen
Synthetic peptide within Human Calnexin aa 543-592
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SN20-54
Conjugate
Unconjugated
Gene
CANX
Gene Alias
1110069N15Rik, AI988026, calmegin, calnexin, canx, canx-a, canx-b, clgn, clnx, cnx, D11Ertd153e, FLJ26570, hypothetical protein, IP90, Major histocompatibility complex class I antigen-binding protein p88, p88, P90, PP90, pp90 precursor
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
29144, 821
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Calnexin, also referred to as IP90, p88 and p90, is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER)
- Many resident ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multisubunit proteins
- Studies indicate that calnexin associates with the major histocompatibility complex (MHC) class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes
- It has been shown that calnexin is a chaperone that retains incompletely or improperly folded proteins in the ER
- The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble ER resident proteins such as GRP78 and GRP94 and protein disulfide isomerase
- Integral membrane ER resident proteins, like calnexin, often lack this KDEL sequence but contain positively charged cytosolic residues that ensure ER retention
- Calnexin contains a large ER luminal domain (461 amino acids), a transmembrane segment (22 amino acids), and a cytoplasmic tail (89 amino acids).