MMP2 Recombinant Rabbit Monoclonal Antibody (SI15-04), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532071-Each-of-1 | In Stock | ₹ 46,413.50 |
PIMA532071 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Antigen
MMP2
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P08253, P33434, P33436
Gene Symbols
MMP2
Immunogen
Synthetic peptide within Human MMP2 aa 101-150
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry, Western Blot
Clone
SI15-04
Conjugate
Unconjugated
Gene
MMP2
Gene Alias
72 kDa gelatinase, 72 kDa type IV collagenase, 72 kDa type IV collagenase isoform a preproprotein, 72kD gelatinase, 72kD type IV collagenase, 72kDa gelatinase, 72kDa type IV collagenase, CLG 4A, CLG4, CLG4A, Collagenase, collagenase type IV-A, endopeptidase, GelA, gelatinase A, Gelatinase alpha, Mat, matrix metallo protease, matrix metallopeptidase 2, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), matrix metalloprotease 2, matrix metalloproteinase, matrix metalloproteinase 2, matrix metalloproteinase 2 (72 KDa type IV collagenase), matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), matrix metalloproteinase-2, matrix metalloproteinase-II, MMP, MMP2, MMP-2, MMP-2 protein, MMP-II, MMPs, MONA, neutrophil gelatinase, PEX, prepro-72kDa matrix metalloproteinase, Progelatinase A, TBE1, TBE-1, wu:fa99h12, wu:fk89d01
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
17390, 4313, 81686
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- MMP (matrix metalloproteinase) are proteolytic enzymes capable of degrading connective tissue components
- MMP have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs)
- MMPa and TIMPs play a significant role in regulating angiogenesis
- MMP2 is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids, and contains the basic structure of propeptide, catalytic, and hemopexin domains
- The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zincendopeptidases
- Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins
- In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc-binding site characterizes the structure of the MMPs
- Functionally, MMP2 is involved in tissue remodeling
- Mutations in MMP-2 gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome
- Two transcript variants encoding different isoforms of MMP-2 have been found.