MMP9 Recombinant Rabbit Monoclonal Antibody (JA80-73), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532705-Each-of-1 | In Stock | ₹ 53,845.00 |
PIMA532705 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,845.00
GST (18%): ₹ 9,692.10
Total Price: ₹ 63,537.10
Antigen
MMP9
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P14780, P50282
Gene Symbols
MMP9
Immunogen
Synthetic peptide within Human MMP9 aa 71-120
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Rat, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
JA80-73
Conjugate
Unconjugated
Gene
MMP9
Gene Alias
67 kDa matrix metalloproteinase-9, 82 kDa matrix metalloproteinase-9, 92 kDa gelatinase, 92 kDa type IV collagenase, 92kD gelatinase, 92kD type IV collagenase, 92kDa gelatinase, 92kDa type IV collagenase, 92-kDa type IV collagenase, AW743869, B/MMP9, Clg4b, collagenase type IVB, fj05a08, Gel B, gelatinase B, Gelatinase-B, GELB, macrophage gelatinase, MANDP2, matrix metallo protease, matrix metallopeptidase 9, matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), matrix metalloproteinase 9, matrix metalloproteinase 9 (gelatinase B 92-kDa type IV collagenase), matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), matrix metalloproteinase 9 (gelatinase B, 92kDa matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase), Matrix metalloproteinase9, matrix metalloproteinase-9, MMP, Mmp9, MMP-9, mmp9 protein, MMP-9 protein, MMPs, Preproform of 92-kDa type IV collagenase (MMP-9): N-terminal, pro-MMP-9, type IV collagenase, type V collagenase, wu:fb02g06, wu:fb07b05, wu:fi98c09, wu:fj05a08, ZFMMP-9, zgc:64165
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
4318, 81687
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- MMP9 (matrix metallopeptidase 9, GELB, CLG4B) is a matrix metalloproteinase, a family of zinc and calcium-dependent endopeptidases that degrade extracellular matrix proteins
- MMP9 is secreted as a 92kDa zymogen and cleavage of pro-MMP9 results in the active enzyme with a molecular weight of 82kDa
- MMP9 has a gelatin-binding domain consisting of three fibronectin type II units, a catalytic domain containing the zinc-binding site, a proline-rich type V collagen-homologous domain and a hemopexin-like domain
- MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts and endothelial cells, and is involved in inflammatory responses, tissue remodeling, wound healing, tumor growth and metastasis
- MMP9 is supplied by bone marrow-derived cells and contributes to skin carcinogenesis
- Further, MMP9 degrades type IV and V collagens
- Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling
- Studies have shown that elevated MMP9 is associated with progression of idiopathic atrial fibrillation and aortic aneurysm.