ASH2L Recombinant Rabbit Monoclonal Antibody (ST47-01), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532147-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532147 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
ASH2L
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
Q91X20, Q9UBL3
Gene Symbols
ASH2L
Immunogen
Recombinant protein within Human ASH2L aa 533-628
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
ST47-01
Conjugate
Unconjugated
Gene
ASH2L
Gene Alias
ASH 2, ASH2, ash2 (absent, small, or homeotic)-like, ash2 (absent, small, or homeotic)-like (Drosophila), ASH2 LIKE, ASH2 like histone lysine methyltransferase complex subunit, ASH2 like protein, ASH2 like, histone lysine methyltransferase complex subunit, Ash2l, ASH2L1, ASH2L2, ash2-like, ASH2-like protein, Bre 2, Bre2, set1/Ash2 histone methyltransferase complex subunit ASH2
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
23808, 290829, 9070
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- The human ASH2L gene encodes a 628 amino acid protein known as ASH2L1, or isoform 1, which contains a nuclear localization signal and PHD finger motif, suggesting that the gene product functions as a transcription regulator
- Its predicted molecular weight is 68.7kDa
- Alternative splicing results in possible isoforms at 60 kDa & 56.5 kDa)
- Human ASH2L proteins are 60% homologous to Drosophila ash2, which positively regulates expression of certain genes in early development, and contain similar, but not identical, domains, including a zinc finger motif
- Homology to mouse ASH2L is 90%
- ASH2L is predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes as well as leukemia cell lines with erythroid and megakaryocytic potential, such as K562, Hel and Dami
- Differentiation inducers (e.g
- phorbol ester and hemin) cause different expression patterns in these cell lines, suggesting that ASH2L plays a role in hematopoiesis and is associated with particular types of leukemia
- In addition ASH2L has been suggested to interact with beta-tubulin and beta-catenin.