Phospho-EGFR (Tyr1173) Recombinant Rabbit Monoclonal Antibody (SC57-04), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532211-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532211 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
Phospho-EGFR (Tyr1173)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P00533
Gene Symbols
EGFR
Immunogen
Synthetic phospho-peptide corresponding to residues surrounding Tyr1173 of Human EGFR .
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SC57-04
Conjugate
Unconjugated
Gene
EGFR
Gene Alias
2.7.10.1, 9030024J15Rik, AI552599, avian erythroblastic leukemia viral (v-erbB) oncogene homolog, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EC 2.7.10.1, egf receptor, Egfr, EGFR-related peptide, epidermal growth factor receptor, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian), Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1), epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1), ERBB, ERBB1, ErbB-1, erb-b2 receptor tyrosine kinase 1, Errb1, Errp, HER1, kinase EGFR, mENA, NISBD2, Oncogene ERBB, PIG61, Proto-oncogene c-ErbB-1, receptor tyrosine-protein kinase erbB-1, Urogastrone, wa2, wa-2, Wa5, waved 2
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
1956
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors
- Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics
- EGFR is encoded by the EGFR gene located on chromosome 7 in humans
- EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4
- EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain
- Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.