VEGF Receptor 1 Recombinant Rabbit Monoclonal Antibody (SY09-09), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532045-Each-of-1 | In Stock | ₹ 48,727.50 |
PIMA532045 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,727.50
GST (18%): ₹ 8,770.95
Total Price: ₹ 57,498.45
Antigen
VEGF Receptor 1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P17948, P35969, P53767
Gene Symbols
FLT1
Immunogen
Synthetic peptide within Human VEGF Receptor 1 aa 1-50
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SY09-09
Conjugate
Unconjugated
Gene
FLT1
Gene Alias
AI323757, embryonic receptor kinase 2, Emrk2, FLT, FLT1, FLT-1, fms related tyrosine kinase 1, FMS-like tyrosine kinase 1, FMS-related tyrosine kinase 1, Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), FRT, i21, sFlt1, soluble VEGFR 1, sVEGFR 1, Tyrosine-protein kinase FRT, tyrosine-protein kinase receptor FLT, Vascular endothelial growth factor receptor 1, vascular endothelial growth factor receptor-1, vascular permeability factor receptor, VEGF R1, VEGFR1, VEGFR-1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
14254, 2321, 54251
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- FLT1 (VEGFR1) is a receptor tyrosine kinase which plays a critical role in angiogenesis
- Active angiogenesis has been found to play important role in many pathological and physiological processes, such as tumor progression, diabetic retinopathy, rheumatoid arthritis and wound healing
- May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells
- Can promote endothelial cell proliferation, survival and angiogenesis in adulthood
- Its function in promoting cell proliferation seems to be cell-type specific
- Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro)
- Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.