RAD18 Recombinant Rabbit Monoclonal Antibody (SN66-01), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532284-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532284 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
RAD18
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
Q9NS91, Q9QXK2
Gene Symbols
Rad18
Immunogen
Synthetic peptide within Human RAD18 aa 50-99
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SN66-01
Conjugate
Unconjugated
Gene
Rad18
Gene Alias
2810024C04Rik, E3 ubiquitin-protein ligase RAD18, hHR18, hRAD18, mRAD18Sc, postreplication repair protein hRAD18p, postreplication repair protein RAD18, post-replication repair protein RAD18SC, Rad18, RAD18 E3 ubiquitin protein ligase, RAD18 homolog, RAD18 homolog (S. cerevisiae), RAD18, E3 ubiquitin protein ligase, RAD18, S. cerevisiae, homolog, Rad18sc, RING finger protein 73, RING-type E3 ubiquitin transferase RAD18, RNF73
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
362412, 56852, 58186
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Human Rad18 (hRad18) is homologue of the S
- pombe Rad18 (3,4)
- In yeast, Rad6 and Rad18 play a crucial role in post-replication repair functions in gap-filling of a daughter strand on replication of damaged DNA (2)
- Furthermore, Rad6-Rad18 interaction is thought to be critical at an early step during lesion bypass in yeast
- In vivo, Rad18 protein forms a tight complex with Rad6 through a conserved ring-finger motif (3,4)
- It has been suggested that Rad18-Rad6 complex binds to the damaged sites by the single-stranded DNA binding property of Rad 18
- This is followed by degradation of the stalled components of DNA replication by ubiquitin-conjugating enzyme activity of Rad6 (1)
- The human Rad18 maps on chromosome 3p24-25, the region which is often deleted in lung, breast, ovary, and testis cancers
- The human RAD18 gene codes for a protein of 495 amino acids with a predicted molecular weight of 56 kDa
- The human Rad18 is ubiquitously expressed in various human tissues.