ZNRF2 Recombinant Rabbit Monoclonal Antibody (JJ0924), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532477-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532477 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
ZNRF2
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
Q71FD5, Q8NHG8
Gene Symbols
Znrf2
Immunogen
Synthetic peptide within Human ZNRF2 aa 162-206
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry, Western Blot
Clone
JJ0924
Conjugate
Unconjugated
Gene
Znrf2
Gene Alias
1190002C14Rik, AU044205, D6Ertd365e, E3 ubiquitin-protein ligase ZNRF2, protein Ells2, RING finger protein 202, RING-type E3 ubiquitin transferase ZNRF2, RNF202, zinc and ring finger 1, zinc and ring finger 2, zinc and ring finger 2, E3 ubiquitin protein ligase, zinc finger/RING finger 2, zinc/RING finger protein 2, Znrf1, Znrf2
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
223082, 362367, 387524
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction
- The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s)
- ZNRF2 (zinc and ring finger 2), also known as RNF202, is a 242 amino acid peripheral membrane protein that contains one RING-type zinc finger and localizes to the lysosome, as well as the endosome and the cell junction
- Expressed at high levels in brain tissue, ZNRF2 is thought to function as an E3 ubiquitin-protein ligase that may be involved in the establishment and maintenance of neuronal transmission and plasticity
- Upon DNA damage, ZNRF2 is subject to phosphorylation, probably by ATR or ATM.