TNFAIP3 Recombinant Rabbit Monoclonal Antibody (SN07-31), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532292-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532292 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
TNFAIP3
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P21580, Q60769
Gene Symbols
TNFAIP3
Immunogen
Synthetic peptide within Human TNFAIP3 aa 491-540
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SN07-31
Conjugate
Unconjugated
Gene
TNFAIP3
Gene Alias
A20, A20p37, A20p50, AISBL, OTU domain-containing protein 7C, OTUD7C, Putative DNA-binding protein A20, RP11-356I2.3, TNF alpha induced protein 3, TNF alpha-induced protein 3, TNFA1P2, TNFAIP3, TNFAIP3 (A20), Tnfip3, Tumor necrosis factor alpha-induced protein 3, tumor necrosis factor induced protein 3, tumor necrosis factor inducible protein A20, tumor necrosis factor, alpha induced protein 3, tumor necrosis factor, alpha-induced protein 3, zinc finger protein A20
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
21929, 7128
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas
- Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas
- TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity
- Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens
- At least two isoforms of TNFAIP3 are known to exist.