CDK8 Recombinant Rabbit Monoclonal Antibody (SN2030), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532343-Each-of-1 | In Stock | ₹ 46,947.50 |
PIMA532343 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,947.50
GST (18%): ₹ 8,450.55
Total Price: ₹ 55,398.05
Antigen
CDK8
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P49336, Q8R3L8
Gene Symbols
Cdk8
Immunogen
Synthetic peptide within Human CDK8 aa 1-50
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
SN2030
Conjugate
Unconjugated
Gene
Cdk8
Gene Alias
Cdk8, CDK8 protein kinase, cell division protein kinase 8, Cell division protein kinase 8-like protein, cyclin dependent kinase 8, cyclin-dependent kinase 8, K35, mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, MGC126074, MGC126075, protein kinase K35, RGD1560888, wu:fk95h11
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
1024, 264064, 498140
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II
- This protein is coexpressed and copurified with Cyclin C
- CDK8 is part of a family of proteins designated as cdks are critical regulators of cell cycle progression
- The prototype member of this family, p34/Cdc 2, and a related protein Cdk 2, function late in the cycle while Cdk 4 and Cdk 6 are critically involved in G1 to S progression
- Because of analogy with yeast Cdk 8, it has been proposed that the human Cdk 8 Cyclin C may interact with RNA polymerase, thus influencing the transcription mechanism(s) that lead to cell division.