PDPK1 Recombinant Rabbit Monoclonal Antibody (SD204-9), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532354-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532354 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
PDPK1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
O15530, O55173, Q9Z2A0
Gene Symbols
Pdpk1
Immunogen
Synthetic peptide within Human PDPK1 aa 1-50
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SD204-9
Conjugate
Unconjugated
Gene
Pdpk1
Gene Alias
3-phosphoinositide dependent protein kinase 1, 3-phosphoinositide dependent protein kinase-1, 3-phosphoinositide-dependent protein kinase 1, 3-phosphoinositide-dependent protein kinase 2 pseudogene, HGNC:8809, hPDK1, isoenzyme 1, kinase isoenzyme 1, lipoamide, mPDK1, OTTHUMP00000174525, OTTHUMP00000205076, PDK1, PDPK1, PDPK2, PDPK2P, Pkb kinase, PkB kinase like gene 1, PkB-like 1, PRO0461, Protein kinase B kinase
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
18607, 5170, 81745
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases
- PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop
- PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate
- Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis
- Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.