ERK5 Recombinant Rabbit Monoclonal Antibody (SD2084), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532389-Each-of-1 | In Stock | ₹ 46,413.50 |
PIMA532389 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Antigen
ERK5
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P0C865, Q13164, Q9WVS8
Gene Symbols
MAPK7
Immunogen
Synthetic peptide within Human ERK5 aa 767-816
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Western Blot, Western Blot
Clone
SD2084
Conjugate
Unconjugated
Gene
MAPK7
Gene Alias
Big MAP kinase 1, BMK1, BMK-1, BMK1 kinase, BNhp-1, BNhp1 kinase, ERK4, ERK5, ERK-5, Erk5-T, extracellular signal regulated kinase 5, extracellular signal-regulated kinase 5, extracellular-signal-regulated kinase 5, MAP kinase 7, MAPK 7, Mapk7, mitogen activated protein kinase 7, mitogen-activated protein kinase 7, PRKM7
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
114509, 23939, 5598
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- MAPK7 (ERK5) serine/threonine kinase is a member of the MAP kinase family and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development
- MAPK7 is activated by mitogen-activated protein kinase 5 (MAP2K5/MEK5) and is involved in downstream signaling processes of various receptors
- In response to extracelluar signals, MAPK7 translocates to the cell nucleus where it regulates gene expression by phosphorylating and activating different transcription factors
- Gene deletion of MAPK7 in mice results in defective blood vessel and cardiac development leading to embryonic lethality
- MAPK7 has been shown to be critical for endothelial function and maintenance of blood vessel integrity
- Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported
- ERK5 is expressed in many adult tissues, abundantly in heart, placenta, lung, kidney and skeletal muscle, but is not detectable in liver.