GAPDH Recombinant Rabbit Monoclonal Antibody (JF81-04), HRP, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532539-Each-of-1 | In Stock | ₹ 46,680.50 |
PIMA532539 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,680.50
GST (18%): ₹ 8,402.49
Total Price: ₹ 55,082.99
Antigen
GAPDH
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and no preservative, pH 7.4
Gene Accession No.
O14556, P00356, P04406, P04797, P16858, Q64467, Q9ESV6
Gene Symbols
GAPDH, GAPDHS
Immunogen
Recombinant full length protein of Human GAPDH aa 1-335
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Chicken, Fish, Human, Mouse, Non-human Primate, Rat
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
JF81-04
Conjugate
HRP
Gene
GAPDHS
Gene Alias
38 kDa BFA-dependent ADP-ribosylation substrate, aging-associated gene 9 protein, BARS-38, bb02e05, cb350, cb609, CDABP0047, EC 1.2.1.12, epididymis secretory protein Li 278, epididymis secretory sperm binding protein Li 162eP, fb71f08, fk58c09, G3PD, G3PDH, GAPD, GAPD2, gapdh, GAPDH2, GAPDH-2, GAPDHS, Gapds, Gapd-s, glceraldehyde-3-phosphate dehydrogenase, glyceraldehyde 3-phosphate dehydrogenase, glyceraldehyde 3-phosphate dehydrogenase, testis-specific, glyceraldehyde phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase (G3PDH), glyceraldehyde-3-phosphate dehydrogenase 2, glyceraldehyde-3-phosphate dehydrogenase GAPDH, glyceraldehyde-3-phosphate dehydrogenase like-17 protein, glyceraldehyde-3-phosphate dehydrogenase type 2, glyceraldehyde-3-phosphate dehydrogenase, spermatogenic, glyceraldehyde-3-phosphate dehydrogenase, testis-specific, glyceraldehyde-phosphate-dehydrogenase, glycerine aldehyde 3-phosphate dehydrogenase, HEL-S-162eP, HEL-S-278, HGNC:4141, HSD35, HSD-35, I79_001391, KNC-NDS6, LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase, testis-specific, mg:bb02e05, MGC128279 protein, MGC88685, multifunctional protein, glycolytic enzyme, OK/SW-cl.12, Peptidyl-cysteine S-nitrosylase GAPDH, similar to glyceraldehyde 3-phosphate dehydrogenase, spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2, Spermatogenic glyceraldehyde-3-phosphate dehydrogenase, Unknown (protein for IMAGE:8101613), unnamed protein product, wu:fb33a10, wu:fb71f08, wu:fk58c09, wu:ft80f05, zgc:76908
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
14433, 14447, 24383, 2597, 26330, 374193, 66020
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) is a catalytic enzyme commonly known to be involved in glycolysis
- GAPDH exists as a tetramer of identical 37-kDa subunits and catalyzes the reversible reduction of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphophate in the presence of NADPH
- Apart from playing a key role in glycolysis, GAPDH is ubiquitously expressed and displays other activities unrelated to its glycolytic function
- GAPDH is reported to be involved in the processes of DNA replication, DNA repair, nuclear RNA export, membrane fusion and microtubule bundling
- Studies provide evidence of GAPDH playing an essential part in gene expression observed in apoptosis and as part of the cellular phenotype of age-related neurodegenerative diseases
- Further, GAPDH is involved in other cellular processes ranging from membrane fusion, and neuronal apoptosis in cancer
- GAPDH is reported to bind to a variety of other proteins, including the amyloid precursor protein, mutations in which cause some forms of Alzheimer's disease (AD), and the polyglutamine tracts of Huntingtin, the protein product aberrant forms of which are causative of Huntington's disease
- Associations between GAPDH, actin and tubulin have also be reported
- Since GAPDH is expressed at high levels in most tissues, it is useful as protein loading control in Western Blot analysis.