HDAC9 Recombinant Rabbit Monoclonal Antibody (JU30-44), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532820-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532820 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
HDAC9
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
Q9UKV0
Gene Symbols
Hdac9
Immunogen
Synthetic peptide within Human HDAC9 aa 1-50
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot, Western Blot
Clone
JU30-44
Conjugate
Unconjugated
Gene
Hdac9
Gene Alias
AV022454, D030072B18Rik, DKFZp779K1053, HD7, HD7b, HD9, HDAC, HDAC7, Hdac7b, HDAC9, hdac-9, HDAC9B, HDAC9FL, HDRP, histone deacetylase 4/5-related protein, histone deacetylase 7B, Histone deacetylase 9, histone deacetylase-related protein, KIAA0744, MEF-2 interacting transcription repressor (MITR) protein, MEF2-interacting transcription repressor MITR, Mitr, mKIAA0744, RGD1310748, RGD1563092, TWIST
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
9734
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin
- The remodeling of chromatin is a critical component of transcriptional regulation and the acetylation of nucleosomal histones is a major source of this remodeling
- Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA
- Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250
- Conversely, the deacetylation of histones is associated with transcriptional silencing
- The histone deacetylases (HDAC) include HDAC1-9
- HDAC9 and HDAC9a are two alternatively spliced isoforms of HDAC9
- HDAC9a is 132 amino acids shorter than HDAC9, but both isoforms contain the HDAC catalytic domain, remain capable of deacetylase activity and repress myoctye enhancer-binding factor 2-mediated transcription
- HDAC9 and HDAC9a are expressed in brain, skeletal muscle, kidney, placenta and pancreas.