OGG1 Recombinant Rabbit Monoclonal Antibody (JA18-13), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532851-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532851 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
OGG1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
O15527
Gene Symbols
OGG1
Immunogen
Synthetic peptide within Human OGG1 aa 296-345
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry, Western Blot
Clone
JA18-13
Conjugate
Unconjugated
Gene
OGG1
Gene Alias
8-hydroxyguanine DNA glycosylase, 8-oxoguanine DNA glycosylase, 8-oxoguanine DNA-glycosylase 1, 8-oxoguanine-DNA-glycosylase, AP lyase, DNA-(apurinic or apyrimidinic site) lyase, DNA-apurinic or apyrimidinic site lyase, HMMH, HOGG1, Mmh, MUTM, N-glycosylase/DNA lyase, OGG1, OGG1 type 1f, OGH1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
4968
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- 8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion
- In E
- Coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine
- One of these enzymes, MutM, was found to have a functional yeast (yOgg1) and human (hOgg1) homologue
- hOgg1 proteins efficiently released the 8-hydroxyguanine opposite the pyrimidine from DNA and cleaved the AP site in a manner similar to bacterial and yeast enzymes
- Genetic backgrounds in control of the repair of damaged DNA are involved in the susceptibility to cancer development
- The hOgg1 gene has been mapped to region 3p26
- 2, a region showing loss of heterozygosity (LOH) in a variety of cancers
- In particular, 3p25-p26 is a common LOH region in lung cancer.