Tyrosine Hydroxylase Monoclonal Antibody (TH-16), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532984-Each-of-1 | In Stock | ₹ 46,947.50 |
PIMA532984 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,947.50
GST (18%): ₹ 8,450.55
Total Price: ₹ 55,398.05
Antigen
Tyrosine Hydroxylase
Classification
Monoclonal
Concentration
100 μg/mL
Formulation
ascites diluted in 1.2% sodium acetate with 2MG BSA and 0.01MG sodium azide
Gene Accession No.
P04177, P07101, P24529
Gene Symbols
TH
Immunogen
Rat tyrosine hydroxylase (TH).
Regulatory Status
RUO
Gene ID (Entrez)
100009362, 21823, 25085, 7054
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Lyophilized
Applications
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone
TH-16
Conjugate
Unconjugated
Gene
TH
Gene Alias
dystonia 14, DYT14, DYT5b, EC 1.14.16.2, HGNC:11782, Th, TH isoform 3, TH isoform a, th1, TH-4, The, TY3H, TYH, TYH antibody, Tyrosine 3-hydroxylase, tyrosine 3-monooxygenase, tyrosine hydroxylase
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rabbit, Rat
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- Reconstitute with 1 mL of PBS buffer to yield a concentration of 100 μg/mL
- Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine
- In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4)
- BH4 binds to the TH catalytic domain, resulting in enzymatic activity
- Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated
- These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains
- TH is also responsible for the conversion of L-tyrosine to L-dopa
- TH plays a key role in the physiology of adrenergic neurons
- The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.