HIF-1 beta Recombinant Rabbit Monoclonal Antibody (2F11), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA533114-Each-of-1 | In Stock | ₹ 50,596.50 |
PIMA533114 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,596.50
GST (18%): ₹ 9,107.37
Total Price: ₹ 59,703.87
Antigen
HIF-1 beta
Classification
Recombinant Monoclonal
Concentration
2.5 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
P27540
Gene Symbols
ARNT
Immunogen
A synthesized peptide derived from human ARNT
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
2F11
Conjugate
Unconjugated
Gene
ARNT
Gene Alias
AHA-1, ARNT, ARNT protein, Arnt1, ARNT1a, ARNT1b, aryl hydrocarbon receptor nuclear translocater, Aryl hydrocarbon receptor nuclear translocator, Aryl hydrocarbon receptor nuclear translocator 1, aryl hydrocarbon receptor nuclear translocator type 1a, aryl hydrocarbon receptor nuclear translocator type 1b, bHLHe2, Class E basic helix-loop-helix protein 2, D3Ertd557e, dioxin receptor, nuclear translocator, Drnt, ESTM42, hif 1, HIF1 beta, HIF-1 beta, Hif1b, HIF1BETA, HIF-1beta, HIF-1-beta, HIF1-beta, hypoxia-inducible factor 1 beta, hypoxia-inducible factor 1, beta subunit, hypoxia-inducible factor 1-beta, mKIAA4051, TANGO, W08714, zgc:136664
Host Species
Rabbit
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
405
Content And Storage
-20°C or -80°C if preferred
Form
Liquid
Related Products
Description
- HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
- HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis
- This occurs as a posttranslational modification by prolyl hydroxylation
- HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits
- Both subunits are constantly translated
- However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes
- Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity
- Therefore, the concentration of HIF-1 alpha increases in the cell
- In contrast, HIF-1 beta remains stable under either condition
- HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
- Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
- HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis
- This occurs as a posttranslational modification by prolyl hydroxylation
- HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits
- Both subunits are constantly translated
- However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes
- Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity
- Therefore, the concentration of HIF-1 alpha increases in the cell
- In contrast, HIF-1 beta remains stable under either condition
- HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
- Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.